Research of the anti-fibrosis factors affecting liver regeneration after partial hepatectomy for hepatic cellular carcinoma with liver cirrhosis

Abstract

Hepatic cellular carcinoma is the third most common cause of cancer deaths in China. Partial hepatectomy is still the most effective treatment for hepatic cellular carcinoma. The liver is an organ with strong regenerative ability, and its regenerative mechanism is very complex. Majority of patients with hepatic cellular carcinoma are accompanied by cirrhosis, and cirrhosis is an important factor affecting the regeneration of the remaining liver after surgery. Liver regeneration is obviously impaired under this condition. However, the anti-liver fibrosis mechanisms behind these processes have not been completely elucidated, the current treatment of fibrosis is merely supportive care, and thus further definition of the anti-liver fibrosis related factors such as keratinocyte growth factor, hepatocyte growth factor, milk fat globule epidermal growth factor 8, collagen-binding vascular endothelial growth factor, ex vivo expansion of circulating CD34+ cells has far-reaching significance for improving their prognosis. This article mainly introduces some relevant factors associated with anti liver fibrosis, for later use of single factor or a combination of multifarious factors to resist liver fibrosis, to provide reference for improving the ability of remained liver regeneration after partial hepatectomy. Key words: Liver regeneration; Liver cirrhosis; Hepatic cellular carcinoma; Anti-fibrosis