Abstract
In this study, with borneol fragments in the crystallized mother liquor of natural borneol used as the raw materials, supercritical carbon dioxide method is adopted for refining to get high purity borneol. The result of the experiment shows that the yield and purity are excellent with an extraction pressure of 11 MPa, an extracting temperature of 40°C, a carbon dioxide flow rate of 25 L·h-1 and an extraction time of 20 minutes. After detected by gas chromatography, the purity of the crystallization products could reach 96%.
Highlights
Borneol (d-Borneol), known as the D-borneol, plum slices, is commonly called camphane alcohol
With borneol fragments in the crystallized mother liquor of natural borneol used as the raw materials, supercritical carbon dioxide method is adopted for refining to get high purity borneol
Natural Borneol exists in five chemical types of camphor fresh leaves volatile oil
Summary
Borneol (d-Borneol), known as the D-borneol, plum slices, is commonly called camphane alcohol. Its molecular formula is C10H18O which can be sublimated; it is the white translucent crystal with strong fragrance of pine and smell of camphor and menthol [1] It has a Melting point of 208 ̊C (racemic), a boiling point of 212 ̊C and a flash point of 65.6 ̊C. It can get the mixture crystalline of borneol and camphor by using steam distillation method, the borneol content is about 84%, camphor content is 14% and others are volatile oil It cannot reach the requirements of “China Pharmacopoeia” 2010 Edition by using the crude extraction process in natural borneol [5] [6]. Even if these borne l fragments were recrystallized and separated, the qualified products could only be improved by 5% - 10% He Hong cheng, et al got 95% purity and 90% yield by using circulating solvent crystallization [9]. In order to get further recycling of borneol fragments in mother liquor, this topic uses Supercritical CO2 extraction technology to extract camphor and borneol of borneol fragments, the extraction of these two components could choose the operating conditions of supercritical fluid extraction-temperature and pressure, it provide a new way for separation and purification and application of supercritical
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