Research of Jiawei-Xiaoyao powder on the Ghrelin, VIP for the non-erosive reflux disease with stagnation of liver Qi and spleen deficiency type

Abstract

Objective To investigate the effect of Jiawei-Xiaoyao powder on the levels of somatotropin and vasoaetive intestinal peptide (VIP) in patients with non-erosive reflux disease (NERD). Methods Seventy patients with liver-stagnation and spleen-deficiency NERD who met the inclusion criteria were divided into two groups according to the random number table, 35 in each group. The treatment group was orally administered with Jiawei-Xiaoyao powder, and the control group was given oral omeprazole enteric-coated tablets and domperidone. Both groups were treated for 8 weeks. Plasma somatotropin and VIP levels were measured by ELISA. Results After treatment, plasma somatotropin levels (210.96 ± 16.85 pg/ml vs. 195.75 ± 12.62 pg/ml, t=4.274) in the treatment group were significantly higher than that in the control group (P<0.01), and plasma VIP level (16.12 ± 1.41 pg/ml vs. 18.57 ± 2.68 pg/ml, t=4.786) in the treatment group was significantly lower than that in the control group (P<0.01). Conclusions The Jiawei-Xiaoyao powder could reduce plasma VIP level in NERD patients, increase plasma somatotropin levels of NERD. Key words: Jia Wei Xiao Yao San; Non-erosive reflux disease; Syndrome of stagnation of liver qi and spleen deficiency; Somatotropin; Vasoactive intestinal peptide