Research of interaction between metronidazole tablets and metal salts `in vitro`

Abstract

Introduction: Along with the efficacy and safety of drugs, the interaction of drugs with each other and with other accompanying substances is important, too. There are no data about the interaction or influence of antacids and other drugs with polyvalent cations on the metronidazole bioavailability. The purpose of this research was the studying of the metronidazole release kinetics from the tablets in an environment that simulates stomach conditions with the addition of metal salts, which are part of the widespread drugs. The research was conducted to assess the impact of possible interactions between the active substance and polyvalent metal cations on their bioavailability and efficacy. Material and methods : Metronidazole tablets were chosen as research object. 0.1 N HCl solution with addition of metal salts was chosen as medium dissolution. The “PharmaTest-DT70” Device with basket, the “Evolution 60S” Spectrophotometer as well as the “AB 204 S/A METTLER TOLEDO” analytical balances were used in the study. Results : Research of chemical interaction between metronidazole and metal salts, which are part of the widespread drugs, in the experiment “in vitro” was carried out. Metal salts don’t influence the metronidazole release from the tablets, as evidenced by dissolution profiles and similarity factors for each of the cases. Conclusions : The chemical interactions between the chosen medicines were not observed in the “in vitro” experiment. Thus, separate intake of metronidazole with other drugs, containing metal cations, is important for further research in the “in vivo” experiment.