Research of Biologically Active Polymeric Hydrogel Transdermal Materials

Abstract

A paper deals with biologically active polymeric hydrogel transdermal materials. It was proved that using humic acids is a perspective for the functional effect on the properties of hydrogel biopolymer materials. Structuring processes and strength characteristics improving are the most changeable while using humic acids. Biologically active polymer hydrogel transdermal materials were designed and produced based on gelatin, hydroxypropyl cellulose, and sodium alginate, modified with lignite humic acids. The peculiarities impact of the received humic substances conditions from lignite on their qualitative and quantitative composition were determined. By carrying out rheological, conductometric, and microscopic studies, it was found that modifying gelatin-sodium alginate and hydroxypropyl cellulose-sodium alginate systems with humic acids allows for receiving polymer hydrogels with a high structuring degree. It has been found that effective processes for receiving biologically active polymer hydrogel transdermal materials based on gelatin, hydroxypropyl cellulose, and sodium alginate can be carried out in different humic acids concentration values while achieving an increase in hydrogel polymer structuring processes. The humic substances’ optimal content in gelatin-sodium alginate systems was found to be no more than 5% by weight.