Abstract
In this paper, the erythrocytes of healthy donors and people with a confirmed diagnosis of COVID-19 were tested by Raman spectroscopy and laser interference microscopy. We argue that erythrocytes (red blood cells) in COVID-19 patients have an irregular shape, and their morphometric characteristics are impaired in comparison to healthy red blood cells. Raman spectroscopy also allows us to detect a decreased oxygen transport function of these erythrocytes. The combination of these methods—Raman spectroscopy and laser interference microscopy—is a highly effective method for the diagnosis of SARS-CoV-2.
Highlights
The situation with the novel coronavirus infection, COVID-19, despite the unprecedented measures taken by the international medical community, remains distressing
The most significant cause of disturbance in the oxygen transport system may be a change in the conformation of hemoglobin hematoporphyrin, as well as its ability to bind oxygen in hemoglobin
The position and intensity of the Raman scattering (RS) bands of the hemoglobin spectrum depend on variations in the bonds in the porphyrin ring; this makes it possible to evaluate hematoporphyrin (HP) conformation, which is directly related to the oxygen-binding properties of hemoglobin [7]
Summary
The situation with the novel coronavirus infection, COVID-19, despite the unprecedented measures taken by the international medical community, remains distressing. Each of them, based on an in-depth analysis of current scientific findings and the current epidemiological situation, administers the provision of medical care to patients with SARS CoV-2 infection with the maximum level of evidence. Hematological disorders, such as thrombocytopenia and lymphopenia with a relatively high neutrophil count and an increased ratio of neutrophils to lymphocytes, are common signs of a severe course of a novel coronavirus infection, while their effects on the state of red blood cells and hemoglobin properties have not yet been studied [2]. Pro-inflammatory cytokines inhibit erythroid progenitor cells, changing their morphology and reducing the lifespan of erythrocytes
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