Research in Exercise Physiology and Dyspnea at McMaster University

Norman L Jones

doi:10.1155/2007/682984

Abstract

Dr EJ Moran Campbell arrived in Hamilton, Ontario, in September 1968, as the founding chairman of the Department of Medicine at McMaster University Medical Centre (Hamilton, Ontario). He had asked me to be the Head of the Regional Respiratory Program, and I followed him two weeks later. We had worked together at the Royal Postgraduate Medical School, Hammersmith Hospital, for several years to develop a system of exercise testing that could be routinely applied to any clinical problem associated with effort intolerance. We also each had our own separate obsessions; Moran’s obsession was in dyspnea, and mine was in exercise metabolism. The three research streams – exercise testing, metabolism and dyspnea – gradually gained momentum, largely due to the hard work of graduate students and fellows. In the present brief overview, I hope to acknowledge their contribution as much as the progress we made in these topics.

Highlights

Dr EJ Moran Campbell arrived in Hamilton, Ontario, in September 1968, as the founding chairman of the Department of Medicine at McMaster University Medical Centre (Hamilton, Ontario)
Cardiac output, circulation, ventilation, pulmonary gas exchange and the patient’s perception of these events are all needed in clinical assessment
Jim Kane joined us from Winnipeg, Manitoba, as chief technologist, and Ann Hart took a leave of absence from Hammersmith Hospital to become our senior research technologist

Summary

Introduction

Measurements of muscle strength, ventilatory capacity (from maximal inspiratory and expiratory flow or volume characteristics), gas transfer capacity and arterialized capillary blood sampling were systematically gathered in all patients with cardiovascular, respiratory and other disorders undergoing exercise testing. The stage 1 test remains the mainstay of our approach to clinical exercise testing, the CO2-based method without (stage 2) or with (stage 3) arterial blood gas sampling is useful in situations in which measurements of cardiac output and pulmonary gas exchange variables are needed [15]. If glycolysis increases to a greater extent than the activation of PDHc, pyruvate accumulates and lactate is Research in exercise physiology and dyspnea formed.

Results

Conclusion