Abstract
The final analysis of KEYNOTE-177 provides further evidence to support the use of pembrolizumab in patients with previously untreated microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer, although there was no significant difference in overall survival compared with chemotherapy. Luis Diaz Jr and colleagues randomly assigned patients to receive intravenous pembrolizumab 200 mg every 3 weeks (n=153) or the investigator's choice of chemotherapy regimen (n=154).
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