Research in Brief

Abstract

Normothermic machine perfusion preservation of deceased donor livers should be considered instead of ischaemic cold storage because it reduces both post-transplant early allograft dysfunction and ischaemic biliary complications, according to the results of the PROTECT trial. James Markmann and colleagues randomly assigned patients awaiting liver donation to receive donor livers preserved by either conventional ischaemic cold storage (control; n=147) or normothermic machine perfusion (n=153). The incidence of early allograft dysfunction was significantly decreased in the normothermic machine perfusion group compared with the control group (27 [18%] of 150 vs 44 [31%] of 141; p=0·01). Histopathological assessment of liver graft biopsies showed that donor livers in the normothermic machine perfusion group had significantly less lobular inflammation, a marker of ischaemia-reperfusion injury. Patient survival at hospital discharge and at day 30 were similar between groups. Use of a Cytosponge biomarker panel to prioritise endoscopic Barrett's oesophagus surveillance: a cross-sectional study followed by a real-world prospective pilotCytosponge atypia, p53 overexpression, and clinical risk factors (age, sex, and segment length) could be used to prioritise patients for endoscopy. Further investigation could validate their use in clinical practice and lead to a substantial reduction in endoscopy procedures compared with current surveillance pathways. Full-Text PDF Open Access