Abstract
目的 研究广州地区汉族类风湿性关节炎患者TNF-β基因第一内含子+252等位基因的单核苷酸替代(G→A)产生的基因多态性,是否与类风湿性关节炎发病的易感性相关.方法 用限制性片段长度多态性-聚合酶链反应(polymerase chain reaction with restriction fragment length polymorphism,PCR-RFLP)技术鉴定120例类风湿性关节炎患者和120例健康对照的基因及基因型,计算其频率,用卡方检验统计显著性.结果 TNF-β+252A等位基因在RA患者组出现的频率明显高于对照组(x2=57.7,P＜0.01,OR=4.476,95%CI:3.009～6.658);RA患者组的TNF-β+252G/TNF-β+252A基因型和TNF-β+252A/TNF-β+252A基因型的频率比对照组显著增高(x2=52.97,P＜0.01).结论 TNF-β+252A等位基因与广东地区汉族人群RA发病强相关,可能是RA的易感基因.具有TNF-β+252G等位基因人群的RA发病率低,该基因可能与RA的耐受性有关。
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