Abstract
BackgroundThe “Paisa Population” is a genetically and culturally homogeneous population of Colombia which has been focus of genetics studies in neuropsychiatric disorders in the last decade. This population is highly affected by major mental disorders, especially Bipolar Disorder. Several studies have been performed trying to understand the genetic basis underlying the disease by evaluating extended pedigrees. Also, the first pharmacogenetic study in this special population is being carried out with the aim to identify genetic variants associated with lithium response in the treatment of bipolar disorder. MethodsHere we will show the ongoing projects on psychiatric genetics in the Paisa Population in both genetics of severe mental illness and pharmacogenetics of lithium response in Bipolar Disorder. ResultsWe will discuss the importance of genetic studies in a genetically isolated and how this potentially more homogeneous population may help to detect common and rare genetic variants underpinning severe mental illness and traits like lithium response. ConclusionsGenetics studies in isolated populations represent an important strategy in the mapping and understanding of genetic basis of complex disorders as bipolar disorder and other mental illnesses. We will show and discuss the ongoing psychiatric genetics studies in the Paisa Population from Colombia.
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