Abstract
As an essential nutrient element for life, iron’s metabolic balance in body tissues is crucial to sustaining normal physiological functions, and it is inextricably related to tumors. Nanotechnology is gaining much attention around the world for cancer treatment. Considering the critical role of iron metabolism, nanocarriers’ toxicity and biocompatibility, novel nanomaterials based on the biochemical activity of iron and the regulatory proteins of iron homeostasis-metabolism show broad application prospects in the field of tumor diagnosis and treatment. In this review, the role of iron-related nanocarriers for tumor therapy, such as iron oxide nanoparticles, Fe-based metal-organic frameworks, ferritin, and transferrin, was reviewed, aiming to help people better understand their tremendous potential in tumor therapy.
Highlights
Cancer is one of the leading causes of death worldwide, posing a serious threat to global public health and harming countless people's quality of life and health
More and more scientists are devoted to exploring new cancer treatment strategies, especially the concept based on drug delivery, which aims to develop drug-delivery vectors to achieve controlled drug release, thereby lessening side effects and advancing the pertinence and effectiveness of treatment
Adjustable size, tailorable framework, and other fascinating physical and chemical properties of nanoparticles (NPs) allow them to be designed as nanoplatforms with specific applications, such as drug delivery and controlled drug release, passive or active targeting to tumors through enhanced permeability and retention (EPR) effects and surface modification, and both diagnostic and therapeutic properties [3]
Summary
Cancer is one of the leading causes of death worldwide, posing a serious threat to global public health and harming countless people's quality of life and health. Adjustable size, tailorable framework, and other fascinating physical and chemical properties of nanoparticles (NPs) allow them to be designed as nanoplatforms with specific applications, such as drug delivery and controlled drug release, passive or active targeting to tumors through enhanced permeability and retention (EPR) effects and surface modification, and both diagnostic and therapeutic properties [3]. This makes nanomaterials one of the most promising cancer treatments to offer personalized cancer therapy with capabilities and efficacy that surpass traditional technologies and methods. This review is anticipated to contribute to understanding the fabulous potential of iron-related NPs in cancer therapy
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