Abstract
To the Editor: I read with interest the article entitled “Influence of High Voltage Pulsed Direct Current on Edema Formation Following Impact Injury” ( Phys Ther 1990;70:219–224), authored by Bettany et al. I thought the article was very timely and well-planned, and I do not have any negative criticisms of the study. I would, however, like to comment on certain design characteristics of the study that future researchers using animal models to study edema may want to keep in mind. First, the effect of anesthesia on lymph flow should be considered. McHale and Thornbury1 found that anesthetics (ie, halothane and pentobarbitone) decreased spontaneous lymphatic contraction in bovine mesenteric lymph vessels. Pentobarbitone also reduced lymphatic vessel contraction induced by electrical stimulation, whereas ether had no effect on lymphatic contractility. Suckert2 also noted that anesthetics could alter the course of edema in rats.… [ ARTICLE][1] [1]: /lookup/volpage/70/219?iss=4
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