Abstract
Vaccines based on human adenovirus 5 (Ad5) induce protective immune responses against several pathogens in animal models, but the neutralising antibodies to Ad5 that most people make are likely to impair the immunological potency of such vaccines. To circumvent this potential problem, researchers have isolated more than 1000 chimpanzee adenovirus strains. Vaccine vectors derived from some of these viruses induce potent cellular immunity in mice. Moreover, in a phase 1 clinical trial, a chimpanzee adenovirus-based vector expressing non-structural hepatitis C virus (HCV) proteins induced broad, sustained T-cell responses to HCV.
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