Abstract
It may surprise some pharmacists that the practice of using vancomycin loading doses is not currently supported by robust clinical evidence. A 2020 consensus guideline from the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists has graded the current evidence with a B-II, which indicates a recommendation neither for nor against the practice. And while many institutional protocols recommend vancomycin loading doses of 20 mg/kg to 35 mg/kg to prevent treatment failure by rapidly reaching therapeutic concentrations, a new study published in the March 2021 issue of Therapeutic Advances in Infectious Disease suggests it may not matter.
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