RESEARCH ANTIFUNGAL THERAPY OF OROPHARYNGEAL CANDIDIASIS IN HIV-INFECTED PATIENTS

Abstract

Modern medicine has made significant advances in the treatment of fungal infections. The problem of drug resistance of such a common conditional pathogen as Candida remains relevant for the last decade. The aims of the study were: 1) analysis of species and strain drift of Candida in patients with HIV/AIDS from oropharynx and intestine in two years; 2) the analysis of the dynamics of the sensitivity of Candida to standard antimycotic drugs. Treatment of candidiasis in HIV-infected patients leads to changes in the species and strain composition of Candida. After eradication of C. albicans which is sensitive to fluconazole, more resistant strains of other species (glabratae, krusei. tropicalis) takes its place in the biotope, which is one of the reasons for the low effectiveness of antimycotic therapy.