Abstract
Nano-drug , a new type drug, is rapidly developing with nanotechnologies in biology and medicine field. The development of nano-drug s will cause the revolution of the diagnosis and treatment. Because Nano-drug carriers have high targeting, favorable sustained, controlled release capability and superior cell penetration ability, it can improve efficacy of drugs and reduce side effects. The role of the object from the target organ, target cell to the most advanced structure in the target cells. The three levels method of targeted therapy all could complete with nanotechnology. Nano-targeting drugs can be divided into passive targeting and active targeting. Current research focuses on the development of functionalized capsules for specific targeting of cancer or immune cells, and on controlling their release properties and targeting functionalities to develop new nano -drug s.
Highlights
Nanomedicine is the application of nanotechnology to medicine [1]
The three levels method of targeted therapy all could complete with nanotechnology
Nano-targeting drugs can be divided into passive targeting and active targeting
Summary
Nanomedicine is the application of nanotechnology to medicine [1]. Nano-drug is taken into cells, to achieve the safe and effective targeted drug delivery and gene therapy. One of the key challenges in the field of bio-nanotechnology for drug delivery systems (DDS) is the development of nano- or micro-sized delivery carriers possessing both targeting functionalities for specific tissues or cells, and controlled release properties for encapsulated drug molecules, proteins and genes [4]. Active targeting of nanoparticles through conjugation of tumor-specific cell surface markers such as tumorspecific antibodies or ligands can enhance the efficacy of nanoparticle drug delivery systems while significantly reducing toxicity [15]. The fundamental physicochemical properties of a nano-drug (its size, charge, hydrophobicity, etc.) can dramatically affect its distribution to cancerous tissue, transport across vascular walls, and retention in tumors The nanoparticle characteristics such as stability in the blood and tumor, cleavability of covalently bound components, cancer cell uptake, and cytotoxicity contribute to efficacy once the nanoparticle has reached the tumor's interstitial space. These properties (both of the nanoparticle and the cancer/tumor under study) can be used to design meaningful in vivo tests to evaluate nanoparticle efficacy [17]
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