Research and Application of Functionalized Mesoporous Silica Supported Quaternary Ammonium Salt Nano-antibacterial Materials

Abstract

Objective: Nano-mesoporous silica has the superior physical properties and special ordered mesoporous structure.It can be used to prepare a surface material with antibacterial activity. Methods: Nano-mesoporous silica has been prepared by TEOS as the silicon source and CTAB as template. In this study, mesoporous silica was synthesized by sol-gel method. In the last, amino surfactants were used as carriers to bind to long chain organic surfactants by surface modification. The mesoporous silica functionalized with long chain quaternary ammonium salt was characterized by infrared spectroscopy, laser particle size and Zeta potential test, and its antibacterial effect was tested. The results show that amino groups are introduced to the surface of mesoporous silica after removing the template, and then dodecyl hydroxyethyl dimethyl ammonium bromide is bound to the surface of mesoporous silica. The combined product has good water solubility and its particle size is about 240 nm.Zeta potential test shows that it can be ionized and has positive charge in pure water. The antimicrobial effect test showed that the material could inhibit the growth and reproduction of DH5α Escherichia coli obviously at room temperature(P<0.05), and had certain antimicrobial activity.