Abstract
Hypoxia inducible factor-1α (HIF-1α)-vascular endothelial growth factor (VEGF)-vascular endothelial growth factor receptor-2 (VEGFR-2) signaling pathway plays a vital role in the regulation of neovascularization, and the activation of this pathway is closely related with tumor invasion and metastasis. Key words: Neoplasms; Neovascularization, pathologic; Vascular endothelial growth factors; Receptors, vascular endothelial growth factor; Signal transduction
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