Research advances in transgenic plant vaccines

Abstract

In recent years, with the development of immunology, genetics and molecular biology, the vaccination programs are taking on a prosperous evolvement. In particular, the technology of the use of transgenic plants to produce human or animal vaccines receives increasing attention. Expressing vaccine antigens in transgenic plants opens up a new avenue for producing oral/edible vaccines. Up to now, many transgenic plant vaccines have been investigated and developed. In this review, recent research advances and basic action mechanisms of transgenic plant vaccines and the issues of high concern, such as the influence on environment and biosafety, are discussed. Special attention is given to the prospects and limitations on transgenic plant vaccines. Key words: Plant, genetically modified; Vaccines; Action mechanism; Biosafety