Abstract
Dysfuntion of α cells plays a critical role in the pathogenesis of diabetes. Its own transcription factors, posttranscriptional modification, transporters related to secretion and paracrine signals from β and δ cells, inflammatory factors, and carbohydrates, lipids, amino acids, all influence α cell function. We summaried the various factors involved in the regulation of α cell function as well as recent related advances on their molecular mechanisms. (Chin J Endocrinol Metab, 2018, 34: 876-881) Key words: Pancreatic αcells; Glucagon; Islet function
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