Abstract
Early-onset epileptic encephalopathy(EEE)represents a group of devastating epileptic disorders that appear in neonatal or infantile period of life, characterized as pharmacoresistant generalized or focal seizures, severe electroencephalography(EEG)abnormalities, mental retardation and behavioral impairments.The interictal epileptic discharges are age-dependent and closely related to cognitive deterioration.EEE includes five epileptic syndromes, which are early myoclonic encephalopathy, ohtahara syndrome, and malignant migrating partial seizures in infancy, West syndrome and Dravet syndrome.The etiologies of EEE are highly heterogeneous, and most of them remain unknown.In many cases with EEE, seizures are resistant to treatment including anti-epileptic drugs and other methods.The prognosis for EEE is poor, and most of the children have severe mental retardation, some even are under the risk of sudden death. Key words: Early-onset epileptic encephalopathy; Epileptic syndrome; Etiology; Treatment
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