Research advances in drug-induced vanishing bile duct syndrome

Abstract

Current evidence shows that drug-induced liver injury has become one of the common causes of acute liver injury in clinical practice. Vanishing bile duct syndrome (VBDS) refers to a syndrome of focal or diffuse disappearance of intrahepatic bile ducts characterized by cholestasis, and drug-induced VBDS (D-VBDS) is one of the important causes of this disease. Most patients with D-VBDS have a good prognosis, but some patients may progress to liver cirrhosis and liver failure. By reviewing the advances in the clinical diagnosis and treatment of D-VBDS, this article points out the difficulty in the diagnosis of D-VBDS, the limited treatment methods for this disease, and poor prognosis in some patients. Therefore, drugs should be used with caution in clinical practice to reduce the incidence and mortality rates of D-VBDS.