Research advancement on interleukin-8 with relevant inflammatory cells of chronic obstructive pulmonary disease

Abstract

Chronic obstructive pulmonary disease (COPD)is leading cause of morbidity and mortality worldwide and results in an economic and social burden. The late researches showed close association of IL 8, with the onset of COPD. As major inflammatory mediators, IL-8 involve in the inflammatory response of airway, which accelerate the onset and progrcss of local inflammation, result in the structural reconstruction of airway and the formation of airflow obstruction and thereby influence the onset and progress of COPD. This paper reviews the association of IL-8 and COPD. Key words: Chronic obstructive pulmonary diseases; Interleukin-8