Abstract

Cholangiocarcinoma (CC) is a malignant tumor arising from the epithelium of the bile ducts. The prognosis of CC is poor due to the difficulty of early diagnosis and limited treatment methods. Radical surgical resection is the only curative treatment method, but about 33% of patients with cholangiocarcinoma have lost their opportunities for surgery at diagnosis. Early diagnosis and early therapy of CC is urgent in clinic. Therefore discovering suitable biomarkers has great significance. In this review, we summarize the research progression of genetic biomarkers of CC from the point of gene mutation and hereditary change. Key words: Bile duct neoplasms; Molecular biology; Genetic markers; DNA mutational analysis; Epigenomics

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