Research advance of mTORC2 signaling pathway in regulation of epithelial sodium channel

Abstract

Mammalian target of rapamycin (mTOR),a serine/threoine protein kinase,is a member of phosphatidy-linositol kinase-related kinase family.It is highly conserved in evolution,which can integrate diverse extracelluar signals,such as nutrients,energy,and growth factors.mTOR plays a critical role in the processes of cell growth,proliferation,apoptosis,and autophagy.In vivo,mTOR forms two distinct multiprotein complexes:mTORC1 and mTORC2.By far,the researches about the relationship between mTORC1 signaling pathway and tumors have been attached greater importance to than mTORC2 signaling pathway.In recent years,several studies found that mTORC2 signaling pathway is involed in the regulation of epithelial sodium channel. Key words: Mammalian target of rapamycin; Epithelial sodium channel; Signaling pathway