Abstract

Advancing female age causes the changes in ovarian function and finally results in reproductive aging. Ovarian aging is characterized by a gradual reduction of follicle number and oocyte quality. Oocyte aging also occurs in the ovaries of reproductive aged female, and ovarian aging is directly associated with a poor fertilizing/developmental competency of oocytes. Therefore treatments to reverse oocyte aging have been a significant issue in assisted reproduction technologies (ART). Recently, inadequate ovarian angiogenesis has been suggested to result in age-related damage of oocytes. A potential therapeutic way which improves poor oocyte quality due to ovarian aging is suggested by the activation of ovarian angiogenesis.

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