Abstract
Many studies have focused on neural changes and neuroplasticity, while the signaling demand for neural modification needs to be explored. In this study, we traced this issue in the organization of brain functional links where the conflictual arrangement of signed links makes a request to change. We introduced the number of frustrations (unsatisfied closed triadic interactions) as a measure for assessing "requirement to change" of functional brain network. We revealed that the requirement to change of the resting-state network has a u-shape functionality over the lifespan with a minimum in early adulthood, and it’s correlated with the presence of negative links. Also, we discovered that brain negative subnetwork has a special topology with a log-normal degree distribution in all stages, however, its global measures are altered by adulthood. Our results highlight the study of collective behavior of functional negative links as the source of the brain’s between-regions conflicts and we propose exploring the attribute of the requirement to change besides other neural change factors.
Highlights
The brain is a malleable organ that adapts to new situations
We decided to study the requirement to change of functional brain network using structural balance theory [17, 18]. We studied this issue across the lifespan to obtain a better view of the approach since there is proper knowledge on the quality of neural change over the lifespan [16, 19, 20] and we can interpret neuroplasticity and requirement to change simultaneously
We wanted to assess the requirement to change of functional brain network using balance theory, compare it over the lifespan stages and investigate relevant network features
Summary
The brain is a malleable organ that adapts to new situations. These situations may have internal or external sources; internally such as genetic polymorphisms, recovery of neural injuries, neural development, systematic reorganization, and externally like behavioral stimuli, social experiences, cognitive-enhancing activities [1,2,3,4,5,6,7]. Strong neuroplasticity helps to modify the neural system in a better way.
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