Required for Adaptive ER-Stress During Testosterone Production in Testis.

Abstract

Male infertility has many causes from hormonal imbalances, to physical problems, to psychological and/or behavioral problems. Heat exposure initiates low serum testosterone levels that could be attributed to downregulated steroidogenic gene such as 3β-HSD and 17β-HSD1 in the testis.Testosterone are required for spermatogenesis; most males with impaired spermatogenesis have low serum testosterone levels. It has been reported that the Leydig cell, which producing testosterone by Luteinizing Hormone(LH), have a highly developed ER. Generally, Endoplasmic Reticulum (ER) stress has been observed in mainly secretory cell type. So we sought to clarify the roles of ER- stress response pathways whether of steroidogenesis and ER stress in male infertility induced repeatedly heat exposure. ER-stress induced by heat exposure are decreased testosterone level, steroidogenic gene but increase expression of ER-stress gene; Bip, p50ATF6.