Reprogramming of mitochondria by proteolysis

Abstract

Mitochondria are central metabolic hubs whose structure and function dynamically adapt to changing metabolic demands and environmental challenges. Metabolic reprogramming of mitochondria occurs during development, cell differentiation, in ageing and disease and is coupled to changes in mitochondrial mass and shape. Similarly, stress conditions and altered metabolic cues induce mitochondrial adaptations, altering proteostasis and lipid homeostasis of mitochondria. ATP-dependent AAA proteases residing in the inner membrane of mitochondria are emerging as central regulators of these adaptive responses.