Abstract
Objective: To assess the reprogramming competence of nuclei from human embryonic and somatic cells, the development of reconstituted bovine oocytes after the transfer of human nuclei was assessed. Nucleus donor cells used in this study are known to retain different characteristics. Embryonal carcinoma (EC) cells are embryonic cells, and many of such cells are in S-phase of the cell cycle. Fetal fibroblast (FF) cells are fetal somatic cells, the most of which are in G1-phase. Cumulus (CM) cells are adult somatic cells presumably in G0-phase. Combining with the further isolation of embryonic stem cells from nuclear-transferred (NT) embryos, this study will assist the use of nuclear transfer technology toward stem cell therapy.
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