Abstract
Background Dendritic cells (DCs) play a crucial role in the development of the adaptive immune response. Unbalance DC response can cause Th1, Th17 or Th2-mediated diseases. By in vitro manipulation, Th2 and Th17 cell lines can be reprogrammed into Th1. This highlights the notion of the plasticity of different populations of CD4 T helper cells. So far, the conversion of Th17 memory cells into Th2 cells has not been demonstrated in the tissues.
Highlights
Dendritic cells (DCs) play a crucial role in the development of the adaptive immune response
Mice were immunized by repetitive administration of inflammatory DCs loaded with OVA protein antigen (OVA-DC), locally or systematically
We propose that immunization with inflammatory DCs, regardless of the route of immunization, induces chronic inflammation of the airways, which is associated with a Th2/Th17 response
Summary
Dendritic cells (DCs) play a crucial role in the development of the adaptive immune response. Unbalance DC response can cause Th1, Th17 or Th2-mediated diseases. Th2 and Th17 cell lines can be reprogrammed into Th1. This highlights the notion of the plasticity of different populations of CD4 T helper cells. The conversion of Th17 memory cells into Th2 cells has not been demonstrated in the tissues
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