Reproductive system status in men after coronavirus infection and vaccination

Abstract

Introduction The COVID-19 pandemic is a serious problem for the health care system in Russia and worldwide, as the pathogenic influence of the pathogen can cause a systematic range of complications in the body, especially in the reproductive system.The aim of the work was to determine the state of the reproductive system in men after coronavirus infection and vaccination based on the analysis of literature data.Materials and methods The search for papers on the state of the reproductive system in men after coronavirus infection and vaccination was conducted in PubMed, Medline, EMBASE and eLibrary.ru databases.Results The reproductive capacity of male patients who have undergone COVID-19 is affected by numerous factors: general health status, activity of the renin-angiotensin-aldosterone system, development of systemic inflammatory response, activation of lipoperoxidation processes, etc. This changes cause inflammatory response in the tissues of the reproductive system, secretion of pro-inflammatory cytokines, imbalance of the antioxidant system, formation of oxidative stress, damage to Leydig and Sertoli cells, formation of reproductive insufficiency and infertility.Discussion The pathogenetic role of SARS-CoV-2 in the development of reproductive depression in men with coronavirus infection, which has a prolonged, negative and persistent effect on the state of testicular hemodynamics, the level of total testosterone in blood and ejaculate parameters, was confirmed.Conclusion The results of the study suggest a deterioration of the reproductive system in men following coronavirus infection.