Abstract
Background: All ages, racial and ethnic groups, including males from all cultural backgrounds, are vulnerable to sexual dysfunction. Although there are few publications on the importance of Moringa oleifera seeds for reproductive organs, it has been stated that they improve aphrodisiac activity. In this study, we investigated the effects of seed extract of Moringa oleifera on the reproductive organ of male Wistar rats. Methods: Sixteen male rats (120-150g, n=4) were grouped as follows: Control, and seed extract of Moringa oleifera (100, 200 and 400mg/ kg). Ethanolic extract of Moringa oleifera seed (EEMS) was given daily for 14 days and thereafter sacrificed by cervical dislocation. Sperm variables were examined microscopically while serum was analyzed for sex hormones, and testicular tissue histopathological. Data were analyzed using Students t-test and ANOVA. Results: Ethanolic extract of Moringa oleifera seed caused a significant increase in body weight, and a decrease in sperm motility, quality, and sex hormones. These declines were dose dependent. Normal histoarchitecture was observed and spermatogenesis was enhanced. Conclusion: Ethanolic seed extract of Moringa oleifera exhibit male reproductive toxicity, as observed from its deleterious effect on andrology and sperm variables.
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