Abstract
Objective: To compare reproductive outcome between women with normal ovarian reserve and women with abnormal ovarian reserve.Design: Retrospective.Setting: Tertiary care center.Patient(s): Nine thousand eight hundred and two patients who had basal follicle-stimulating hormone (FSH) concentrations measured as part of an infertility evaluation.Intervention(s): Monitoring of early pregnancy.Main Outcome Measure(s): Pregnancy loss rates, live birth rates.Result(s): Of 1,034 patients with diminished ovarian reserve (DOR) (FSH ≥14.2 IU/L), 28 (2.7%) conceived. Twenty of these pregnancies (20/28; 71.4%) were lost in the first trimester. Pregnancy loss rates in women with DOR were 57.1% in women <35 years old, 63.5% in women 35–40 years old, and 90.0% in women >40 years old. These rates of pregnancy loss were significantly higher compared to age-matched patients with normal ovarian reserve.Conclusion(s): Women with DOR have exceedingly high rates of pregnancy loss, regardless of age. Women with diminished ovarian reserve should be counseled that, in addition to a low probability of conception, live birth rates are poor.
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