Abstract
The present study was designed to investigate the effects of the antimicrobial agent ciprofloxacin on male fertility as well as some liver and kidney function tests in male rats. In addition, some hematological and histopathological investigations were also studied. The animals were divided into three equal groups, each of 15 rats. The first and second groups given 30 and 60 mg/ kg B.wt. ciprofloxacin orally for ten days using stomach tubes. The third group was given saline and kept as a control. ciprofloxacin induced mild to moderate toxic effects on the reproductive parameters especially reproductive organs weight and semen characteristics , as well as liver and kidney functions in male rats. Attention should be paid on using higher doses of ciprofloxacin. That's due to the resultant fertility problems due to abnormal semen characters in addition to a significant toxic effect of the drug on liver and kidneys .
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