Abstract
Crl:CD(SD)rats were given 3-cyanopyridine by gavage at 0, 5, 30 or 180mg/kg/day. Males were dosed for 42 days beginning 14 days before mating, and females for 40–53 days beginning 14 days before mating to day 3 of lactation, including throughout the mating and gestation periods. General toxicity, mainly liver damage, was observed in males at ≥30mg/kg/day and in females at ≥5mg/kg/day. Sertoli cell vacuolation was observed at 180mg/kg/day, and spermatocyte damages were observed at ≥30mg/kg/day. Effects on estrous cycles, corpora lutea and implantations, and unsuccessfully mated females, despite additional mating, were observed at 180mg/kg/day. Delayed initiation of delivery, dystocia, and deaths or moribundities of pregnant females were observed at 180mg/kg/day, and only two pregnant rats delivered live pups at that dose. The NOAEL for reproductive/developmental toxicity was concluded to be 30mg/kg/day.
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