Abstract
The effect of Welch's Special Grape Color Powder Type BW-AT on reproductive performance was studied through two generations of Sprague-Dawley rats and a subchronic study was carried out on the F 1 animals. The grape colour powder at dietary levels of 7.5 and 15.0% (w/w) had no adverse effects on reproductive performance. Body weights for F 0 and F 1 generation pups at both dose levels were significantly lower ( P < 0.05) than those of control pups at 21 days after birth. During the 13-wk subchronic feeding study of F 1 rats, the body-weight gain of female rats in the high-dose group was reduced compared with the controls ( P < 0.05). Food conversion data was comparable among groups, thus the decrease in body-weight gain during this phase was most likely the result of the lower calorific value (w/w) of the feed supplemented with the grape colour powder compared with the control feed. No toxic effects or pathological changes were noted in rats fed grape colour powder.
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