Reproducibility of the Specialized PArticulate Control Environmental Exposure Unit (SPAC-EEU) as a Novel Controlled Cat Dander Exposure Room

Abstract

Allergic rhinitis (AR) induced by cat allergens, most commonly to Felis domesticus allergen 1 (Fel d 1), is estimated to affect 10-20% of the world’s population. Accurate and reproducible clinical models of prolonged cat allergen exposure are limited. Using our Specialized PArticulate Control Environmental Exposure Unit (SPAC-EEU), we sought to assess the capacity of our equipment to accurately and reproducibly distribute cat allergen.