Reproducibility of maximal quadriceps strength and its relationship to maximal voluntary activation in postpoliomyelitis syndrome

Abstract

Horemans HL, Beelen A, Nollet F, Jones DA, Lankhorst GJ. Reproducibility of maximal quadriceps strength and its relationship to maximal voluntary activation in postpoliomyelitis syndrome. Arch Phys Med Rehabil 2004;85:1273–8. Objectives To determine what changes in maximal isometric strength can be detected in a symptomatic quadriceps muscle in patients with postpoliomyelitis syndrome (PPS) and to investigate the association between the variability in maximal strength and maximal voluntary activation (MVA). Design Repeated-measures over a 3-week interval. Setting University hospital. Patients Convenience sample of 65 patients with PPS. Intervention Dynamometer testing. Main outcome measures Maximal voluntary contraction (MVC) torque of the quadriceps was measured with a Kin-Com dynamometer and MVA was determined by twitch interpolation. Results The mean difference between the 2 consecutive measurements was −0.7±12.8Nm (95% confidence interval [CI], −3.9 to 2.5). The test-retest reliability was excellent for MVC torque (intraclass correlation coefficient [ICC]=.96; 95% CI, .93–.98) and moderate for MVA (ICC=.73; 95% CI, .56–.85). The smallest detectable change in MVC torque was 25% for an individual. The variability in MVA explained 18% of the variability in maximal strength. Conclusions Variability in maximal quadriceps strength, measured with a fixed dynamometer, was large and partly related to variability in MVA. This implies that even with optimally standardized strength testing, a follow-up of many years is required to objectify progression of quadriceps weakness in an individual patient with PPS. To demonstrate changes in strength in groups of patients in follow-up or intervention studies, feasible sample sizes are required.