Abstract
The reproducibility of ultrasound-induced hemorrhage near the fetal rat skull is important in therapy and related bioeffect studies. A 0.92-MHz f/1 spherically focused transducer (5.1-cm focal length) was used to expose the skull of 18- to 19-day-gestation exteriorized rat fetuses (9.6−μs pulse duration). The fetuses were exposed to one of four exposure conditions (denoted A, B, C, and D) in addition to a sham exposure. Three of the exposures consisted of a peak compressional pressure of 10 MPa, a peak rarefactional pressure of 6.7 MPa, and PRFs of 100 Hz (A), 250 Hz (B), and 500 Hz (C), corresponding to time-average intensities of 1.9, 4.7, and 9.4 W/cm2, respectively. Exposure D consisted of a peak compressional pressure of 6.7 MPa, a peak rarefactional pressure of 5.0 MPa, and a PRF of 500 Hz corresponding to a time-average intensity of 4.6 W/cm2. The hemorrhage sizes were 1.4±0.7 mm2 for A (occurrence of 15). a)Currently at Electrical Engineering Department, University of North Dakota, Grand Forks, ND 58202.
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