Abstract
AimThe aim of the study is to compare the measurements of central corneal thickness (CCT) performed by two examiners with four different methods at different times inter- and intra-individually.MethodsThirty healthy people were included in the study. In these measurements, an optical low-coherence reflectometry (OLCR), an optic coherence tomography (OCT), a specular microscopy (SM), and a corneal topography (CT) were used. Two examiners performed the measurements in a consecutive manner. After 1–7 days of the first measurements, the second measurements were performed again consecutively. The mean of three measurements was taken in each session for all devices.ResultsIn OCT measurements, there was a significant difference between two examiners in both sessions (p < 0.001), while no significant differences were found between two examiners in first and second sessions in SM, CT, and OLCR measurements. When each examiner’s measurements were compared to two sessions, there were no significant differences (p > 0.05, for all) except the SM measurements of the first examiner (p = 0.041). When the first measurements of two examiners were compared, the smallest values were of OCT. At the first session of two examiners, there was a significant difference between OCT and CT measurements, and between OCT and OLCR (p < 0.001, p = 0.002 for the first examiner and p < 0.001 for the second examiner, respectively).ConclusionOur study showed that CCT measurements made by CT and OLCR methods were almost same and highly correlated for both the examiners’ measurements. CCTs measured by OCT were on average 30 μm thinner than CT and OLCR.
Highlights
Central corneal thickness (CCT) has a great deal of importance in the diagnosis and follow-up of glaucoma and refractive surgical interventions such as cross-linking [1]
A powerful correlation was found between the measurements of the two sessions in the specular microscopy (SM), corneal topography (CT), and optical low-coherence reflectometry (OLCR) methods, while a correlation of an intermediate level was present between the measurements performed using optic coherence tomography (OCT) equipment (r: 0.747, r: 0.691, Table 1, respectively)
When the two investigators were compared with each other based on the measurements obtained, the measurements by both investigators using SM, CT, and OLCR were similar; OCT measurements by the two investigators were different from each other, both in the first (p \ 0.001) and second sessions (p \ 0.001) (Table 3)
Summary
Central corneal thickness (CCT) has a great deal of importance in the diagnosis and follow-up of glaucoma and refractive surgical interventions such as cross-linking [1]. In this method, there are some limitations, such as direct contact of the equipment with the cornea, measurement of the estimated central point, limited definition of the thinnest point of the cornea, and variation according to the individual performing the measurement. There are some limitations, such as direct contact of the equipment with the cornea, measurement of the estimated central point, limited definition of the thinnest point of the cornea, and variation according to the individual performing the measurement Devices such as optical, low-coherence reflectometry, optical coherence tomography, noncontact specular microscopy, and corneal topography have been developed to measure CCT with a noncontact optic method [3]. The reliability of the CCT measurements is very important in the diagnosis and management of various corneal diseases [2]
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