Abstract

BackgroundHypofractionated radiotherapy has been used for the treatment of AVMs and brain metastases. Hypofractionation necessitates the use of a relocatable stereotactic frame that has to be applied on several occasions. The stereotactic frame needs to have a high degree of reproducibility, and patient positioning is crucial to achieve a high accuracy of the treatment.MethodsIn this study we have, by radiological means, evaluated the reproducibility of the isocenter in consecutive treatment sessions using the Fixster frame. Deviations in the X, Y and Z-axis were measured in 10 patients treated with hypofractionated radiotherapy.ResultsThe mean deviation in the X-axis was 0.4 mm (range -2.1 – 2.1, median 0.7 mm) and in the Y-axis -0.3 mm (range -1.4 – 0.7, median -0.2 mm). The mean deviation in the Z-axis was -0.6 (range -1.4 – 1.4, median 0.0 mm).ConclusionThere is a high degree of reproducibility of the isocenter during successive treatment sessions with HCSRT using the Fixster frame for stereotactic targeting. The high reducibility enables a safe treatment using hypofractionated stereotactic radiotherapy.

Highlights

  • Hypofractionated radiotherapy has been used for the treatment of arteriovenous malformations (AVMs) and brain metastases

  • Hypofractionated stereotactic radiotherapy (HCSRT) may be more appropriate than single fraction radiosurgery (SRS) for the treatment of large lesions or lesions located in eloquent areas

  • In this study we have evaluated the clinical reproducibility of the total set up procedure in consecutive treatment sessions of patients with brain metastases using the relocatable Fixster frame

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Summary

Introduction

Hypofractionated radiotherapy has been used for the treatment of AVMs and brain metastases. Hypofractionation necessitates the use of a relocatable stereotactic frame that has to be applied on several occasions. Hypofractionated stereotactic radiotherapy (HCSRT) is a method of delivering stereotactic irradiation in a few fractions using a relocatable stereotactic frame. This treatment is currently used for the treatment of arteriovenous malformations (AVMs) [1-4] and brain metastases [5,6]. Fractionated stereotactic radiotherapy may provide a radiobiological advantage over SRS in the treatment of malignant tumours [7]. HCSRT has been used for the treatment of AVMs and single or oligo brain metastases since 1986 at Umeå university Hospital. The dose was normalized and specified to the center of the target and the (page number not for citation purposes)

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