Abstract
Glucocorticoid receptor negatively regulates expression of the human glycoprotein hormone a-subunit gene through glucocorticoid receptor binding sites that overlap DNA elements (CREs) crucial for both cAMP responsiveness and placental-specific expression of this gene. Negative regulation can be conferred by this 52 bp region to a heterologous promoter; however, it is observed only under circumstances where the CREs act as transcriptional enhancers. These data support the hypothesis that steroid receptors repress gene expression by binding to sites which overlap those of other important transcription factors, thereby disrupting their actions.
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