Repositioning Natural Products in Drug Discovery

Giulio Rastelli,Federica Pellati,Luca Pinzi,Maria Cristina Gamberini

doi:10.3390/molecules25051154

Giulio Rastelli, Federica Pellati + Show 2 more

Open Access

https://doi.org/10.3390/molecules25051154

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Journal: Molecules	Publication Date: Mar 4, 2020
Citations: 35	License type: CC BY 4.0

Affiliation: University of Modena and Reggio Emilia

Abstract

Drug repositioning (o repurposing) has become one of the most popular and successful strategies to reduce failures typically associated with drug discovery [...].

Highlights

In light of all the above, this Special Issue will focus on computational and experimental approaches in the research area of repurposing natural products, including studies on, but not limited to, the identification of new biological targets of natural compounds, the discovery of bioactive natural and/or nature-inspired compounds by in silico screening, their isolation and characterization, de-replication of natural extracts, analysis of structure–activity relationships of natural bioactive compounds
Drug repositioning (o repurposing) has become one of the most popular and successful strategies to reduce failures typically associated with drug discovery [1]
It involves the identification of novel biological targets and different therapeutic uses of already approved and/or investigational drugs, including drugs that did not meet the primary therapeutic expectations

Summary

Introduction

In light of all the above, this Special Issue will focus on computational and experimental approaches in the research area of repurposing natural products, including studies on, but not limited to, the identification of new biological targets of natural compounds, the discovery of bioactive natural and/or nature-inspired compounds by in silico screening, their isolation and characterization, de-replication of natural extracts, analysis of structure–activity relationships of natural bioactive compounds. Drug repositioning (o repurposing) has become one of the most popular and successful strategies to reduce failures typically associated with drug discovery [1]. It involves the identification of novel biological targets and different therapeutic uses of already approved and/or investigational drugs, including drugs that did not meet the primary therapeutic expectations.

Results

Conclusion