Abstract
Repositioning of cell-specific Transcription Factor Regulatory Networks (TFRNs) into another cell type is a pragmatic approach to elicit desired functions in impaired cells and also to investigate transcription regulations underlying cellular functions. However, a systematic method to identify a set of transcription factors (TFs) which can efficiently promote TFRN in a foreign cell type is lacking. Here, we demonstrate a perturbation-matrix method for the identification and repositioning of monocyte TFRNs in dermal fibroblasts.
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