Reporting of drug reaction with eosinophilia and systemic symptoms from 2002 to 2019 in the US Food and Drug Administration Adverse Event Reporting System

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a drug-induced severe cutaneous adverse reaction that is often overlooked owing to its overlap with other infectious and inflammatory illnesses; however, early identification and treatment are important to preventing associated morbidity and mortality.1,2 Historically, anticonvulsant use in association with DRESS syndrome was cited as early as the 1930s, with initial descriptions involving drug-associated hypersensitivity.2 In the 1950s, the term “drug-induced pseudolymphoma” described syndromes of cutaneous symptoms with organ involvement and other systemic features.