Report of the GUARDIAN-LUNG Registry: An Analysis of Advanced Hypothermic Preservation on Lung Transplantation

Abstract

Purpose To assess the safety and efficacy of the LUNGguard Donor Lung Preservation System compared to conventional ice storages on lung transplant recipient perioperative and short-term clinical outcomes. Methods The Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs (GUARDIAN-LUNG) study is a multi-center retrospective-prospective registry assessing clinical outcomes after lung transplantation. This is the initial report of a study comparing two methodologies of hypothermic storage: patients with donor lungs preserved by the LUNGguard and patients with donor lungs transported by conventional preservation methods (ice protocol). Data on baseline donor, recipient, and procedure characteristics are captured and reported using descriptive statistics for the two cohorts. Propensity score matching between cohorts to control for bias will be utilized to compare outcomes. Endpoints Comparisons will be made on peri-operative and short-term patient outcomes including Primary Graft Dysfunction Grade 3 during the first 72 hours, posttransplant ECMO, infections requiring treatment during initial hospitalization, and 90-day/index hospitalization mortality rates. To assess the safety and efficacy of the LUNGguard Donor Lung Preservation System compared to conventional ice storages on lung transplant recipient perioperative and short-term clinical outcomes. The Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs (GUARDIAN-LUNG) study is a multi-center retrospective-prospective registry assessing clinical outcomes after lung transplantation. This is the initial report of a study comparing two methodologies of hypothermic storage: patients with donor lungs preserved by the LUNGguard and patients with donor lungs transported by conventional preservation methods (ice protocol). Data on baseline donor, recipient, and procedure characteristics are captured and reported using descriptive statistics for the two cohorts. Propensity score matching between cohorts to control for bias will be utilized to compare outcomes. Comparisons will be made on peri-operative and short-term patient outcomes including Primary Graft Dysfunction Grade 3 during the first 72 hours, posttransplant ECMO, infections requiring treatment during initial hospitalization, and 90-day/index hospitalization mortality rates.