Abstract
The Second International Workshop on CMV & Immunosenescence was held in Cambridge, UK, 2-4th December, 2010. The presentations covered four separate sessions: cytomegalovirus and T cell phenotypes; T cell memory frequency, inflation and immunosenescence; cytomegalovirus in aging, mortality and disease states; and the immunobiology of cytomegalovirus-specific T cells and effects of the virus on vaccination. This commentary summarizes the major findings of these presentations and references subsequently published work from the presenter laboratory where appropriate and draws together major themes that were subsequently discussed along with new areas of interest that were highlighted by this discussion.
Highlights
The first International Workshop on CMV & Immunosenescence was held in Tubingen, Germany, December 2009
The discussions focused on trying to define what immunosenescence is exactly, the phenotypes of the cells associated with it and what evidence was available that long term carriage of HCMV into old age was detrimental to health as assessed either by measuring allcause mortality or degradation of the immune system such that older HCMV-seropositive individuals respond less well to neo-antigens such as seasonal influenza vaccination
It was felt that higher HCMV IgG levels might reflect this, but in many sick people they stay the same, so did this mean that HCMV was not reactivating? A study of elderly people suffering from acute bacterial infections (e.g. S. pneumonia, E. coli, S. aureus, K. pneumonia) did not show any reactivation of CMV infections measured by IgM antibodies (n = 20)
Summary
The first International Workshop on CMV & Immunosenescence was held in Tubingen, Germany, December 2009. The seminar presentations covered four separate sessions: cytomegalovirus and T cell phenotypes; T cell memory frequency, inflation and immunosenescence; cytomegalovirus in aging, mortality and disease states; and the immunobiology of cytomegalovirus-specific T cells and effects of the virus on vaccination. This commentary summarizes the major findings of these presentations and references subsequently published work from the presenter laboratory where appropriate and draws together major themes that were subsequently discussed along with new areas of interest that were highlighted by this discussion
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