Abstract
The 37th San Antonio Breast Cancer Symposium (SABCS) was held at the Henry B. Gonzalez Conference Centre in San Antonio, Texas, USA between the 9 and 13th of December 2014. It brought together an interaction between basic scientists and clinicians involved in the management of breast cancer. The symposium included six general sessions, poster discussion, and poster sessions. The most important highlights in the fields of advancing endocrine therapy; hormone receptor positive advanced breast cancer and hormonal resistant therapy; targeted therapies; genetics and genomics; supportive (adjunct) care; chemotherapy treatments; breast screening and risk stratification; male breast cancer and future potential directions were included here.
Highlights
They identified a significant improvement in overall survival (OS) for invasive lobular cancer treated with anastrozole compared to tamoxifen (HR 0.56, 95%confidence interval (CI) 0.34–0.92) and this was replicated in diseasefree survival (DFS) and OS for luminal B subtypes but not luminal A
Dr Prudence Francis from the International Breast Cancer Study Group on behalf of colleagues described a randomised comparison of adjuvant tamoxifen (T) plus ovarian function suppression (OFS) versus tamoxifen in premenopausal women with hormone receptor-positive (HR+) early breast cancer (BC): analysis of the suppression of ovarian function (SOFT) trial [2]
Five year overall survival was 94.5% for T+OFS and 90.9% for T (HR = 0.64; 95% CI, 0.42–0.96), with the cohort who remained premenopausal after chemotherapy experiencing a 4.5% absolute improvement in five-year breast cancer free interval (BCFI) with T+OFS versus T
Summary
Copyright: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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